Association of serum Cystatin C,hypersensitive C reactive protein level and the carotid intima-media thickness in patients with type 2 diabetes mellitus
10.3969/j.issn.1671-8348.2014.24.014
- VernacularTitle:2型糖尿病患者血清胱抑素-C、超敏C反应蛋白与颈动脉内中膜厚度的相关性
- Author:
Wei LU
;
Qing WANG
;
Haiying LI
- Publication Type:Journal Article
- Keywords:
diabetes mellitus,type 2;
Cystatin C;
hypersensitive C-reaction protein;
Carotid intima-media thickness
- From:
Chongqing Medicine
2014;(24):3160-3162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum Cystatin C (CysC) ,hypersensitive C-reactive protein (hs-CRP) level and the carotid intima-media thickness(IMT) in patients with type 2 diabetes mellitus(T2DM) .Methods 85 patients with T2DM were divided into two groups according to IM T level :Normal IM T group and IM T increased group .40 healthy people were chosen as control .The level of CysC and hs-CRP were measured and IMT of the carotid artery was determined by color Doppler ul-trasonography in 85 diabetics and 40 normal subjects .Results The CysC levels in IMT increased group was higher than normal IMT group and control group(P<0 .05) .The hs-CRP level in IMT increased group was higher than that in the normal IMT group and control group(P<0 .01) .The analysis of correlation indicated that the level of hs-CRP had positive correlation with IMT .And there was no association between serum CysC level and carotid IMT (r=0 .104 ,P>0 .05) .Conclusion There is no definite correla-tion between serum CysC level and carotid IMT in patients with type 2 diabetes mellitus .Serum CysC level is not predictive index in carotid intima-media thickness of T2DM .Inflammatory play an important role in early carotid atherosclerosis in patients with T2DM .
