Effect of lipide diet on the pharmacokinetics of levofloxacin in Beagle dogs
10.3969/j.issn.1671-8348.2014.24.023
- VernacularTitle:脂质饮食对B eag le犬体内左氧氟沙星药动学的影响
- Author:
Chengzhi ZHANG
;
Fuchun LIU
;
Hang SONG
- Publication Type:Journal Article
- Keywords:
lipide diet;
levofloxacin;
pharmacokinetics;
Beagle dog
- From:
Chongqing Medicine
2014;(24):3184-3186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of lipide diet on pharmacokinetics of levofloxacin (Lfox) in beagle dogs .Methods In randomized cross over experiment ,6 Beagle dogs were given Lfox 10 mg/kg at the condition of empty stomach or with lipide diet for 2 week .Plasma concentration of Lfox was determined by HPLC at different time (during 48 h) .The pharmacokinetic parameters were calculated by 3p97 software .Results The plasma concentration-time curves were two compartment modelat the condition of empty stomach or lipide diet .Main pharmacokinetic parameters were as follows :t1/2β:(11 .07 ± 8 .46)and(21 .79 ± 4 .59)h ;tmax :(3 .42 ± 0 .41) and(2 .00 ± 0 .32)h;Cmax :(2 .71 ± 0 .60)and(2 .52 ± 0 .38)μg/mL ;AUC0→ t :(36 .51 ± 8 .66) and(37 .19 ± 8 .21)μg · h-1 · mL -1 ,respectively .There were significant differences in pharmacokinetic parameters of tmax (P<0 .01)except for t1/2β、Cmax and AUC0→ t .Conclusion Lipide diet can quicken tmax ,has no effect on the absorption of Lfox .
