Clinical study of nicergoline and aniracetam in treatment of mild and moderate cognitive dysfunction after cerebral infarction

VernacularTitle:尼麦角林与茴拉西坦治疗脑梗死后轻中度认知功能障碍的临床研究
Author: Lang CHEN ; Fei XIAO
Publication Type:Journal Article
Keywords: nicergoline; cerebral infarction; cognition
From: Chongqing Medicine 2014;(22):2886-2887
CountryChina
Language:Chinese
Abstract: Objective To observe the clinical efficacy and safety of nicergoline and aniracetam in treatment of mild and moderate cognitive dysfunction after cerebral infarction .Methods Infarction were enrolled after 70 cases of mild and moderate cognitive im-pairment patients were randomly divided into nicergoline treatment group (observation group) and aniracetam treatment group(con-trol group) ,all 35 cases .After 12 weeks of treatment were compared before and after treatment mini mental state examination (MMSE) ,activities of daily living scale(ADL) scores and transcranial Doppler(TCD) to improve the situation .Results After 12 weeks ,both groups after treatment compared with treatment MMSE score was significantly higher (P< 0 .05) ,and nicergoline group than aniracetam group(P< 0 .01);ADL score before treatment were significantly reduced (P< 0 .05) ,TCD improvement nicergoline group than aniracetam group (P<0 .01) .Conclusion Nicergoline mild and moderate cognitive dysfunction after cerebral in-farction have significant effects ,and better than aniracetam ,no significant adverse reactions occur for a wide range of clinical applications .