Expression and significance of TGF-β1 and its type I receptor ALK1 in human brain glioma

VernacularTitle:TGF-β1及I型受体 ALK1在人脑胶质瘤细胞的表达及意义
Author: Jiugeng FENG ; Ronghua FENG ; Tao HONG ; Shan XU ; Xuanyong YANG ; Chunhui ZENG
Publication Type:Journal Article
Keywords: transforming growth factor beta1; activin-like kinase 1; human brain glioma
From: Chongqing Medicine 2014;(24):3139-3142
CountryChina
Language:Chinese
Abstract: Objective To study the expression of transforming growth factor beta1(TGF-β1)and its type I receptors activin-like kinase 1(ALK1)in the human brain glioma and estimate the significance in the pathogenisis and development of human glioma . Methods The mRNA and protein expressions of TGF-β1 and ALK1 were detected with semiquantitative RT-PCR ,Western blot and Immunohistochemistry in 3 normal brain tissues and 32 patiens with human glioma .Results ALK1 and TGF-β1 mRNA and protein sometimes had co-expression in human gliomas tissues .Compared with those normal brain tissues ,the expression of TGF-β1 and ALK1 mRNA and protein in high grade gliomas were significantly increased (P<0 .05) ,the overexpression of ALK1 in human gliomas was demonstrated significant positive correlation with the pathological grades of gliomas (r=0 .297 ,P<0 .05) .Conclusion The overexpression of ALK1 may play important role in the development of human brain glioma .