Research progress of therapeutic effect of hyaluronic acid-paclitaxel nanoparticles in tumors
10.3760/cma.j.issn.1006-9801.2014.08.021
- VernacularTitle:透明质酸-紫杉醇纳米制剂在肿瘤治疗中的研究进展
- Author:
Wenjing LI
;
Liuyang HE
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Hyaluronic acid;
Paclitaxel;
CD44;
Targeted
- From:
Cancer Research and Clinic
2014;26(8):568-570
- CountryChina
- Language:Chinese
-
Abstract:
Paclitaxel is one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers.However,its clinical application has been limited due to its poor water solubility.Its current clinical administration results in serious side effects and has undesired pharmacokinetics and biodistribution.Therefore,it is need to develope alternate drug delivery systems of paclitaxel to enhance its solubility,permeability and stability,furthermore to promote a sustained,controlled and targeted delivery.Hyaluronic acid as the carrier of drug delivery system can solve the problems.Hyaluronic acid-paclitaxel nanoparticles have high anticancer efficiency in drug encapsulation and tumor cellular uptake,due to their appropriate size,surface modification and interaction with CD44.This review focuses on recent applications of hyaluronic acid-paclitaxel nanoparticles in a variety of malignant tumors.
