Resting state functional magnetic resonance imaging of the hippocampus after ischemic stroke
10.3760/cma.j.issn.0254-1424.2014.07.005
- VernacularTitle:缺血性脑卒中认知功能障碍患者静息态下海马功能连接的功能性磁共振成像研究
- Author:
Cai JIANG
;
Shanli YANG
;
Jing TAO
;
Jia HUANG
;
Haicheng YE
;
Zhicheng LIN
;
Lidian CHEN
- Publication Type:Journal Article
- Keywords:
Stroke;
Functional magnetic resonance imaging;
Resting state;
Cognition;
Hippocampus;
Brain connectivity
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2014;36(7):517-522
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the functional connectivity (FC) pattern linking the hippocampus with the rest of the brain in ischemic stroke patients with cognitive dysfunction,especially the default mode network (DMN).Methods Resting-state functional connectivity magnetic resonance imaging (fMRI) was performed on 15 ischemic stroke patients with cognitive dysfunction (the patient group) and 10 normal elderly controls.The bilateral hippocampus was the region of interest.Correlation analyses yielded a mapping of cerebral functional connectivity activation for both groups.Results Compared with the healthy controls,the patient group showed weakened functional connectivity between the hippocampus and other regions including the cingulate gyrus,the superior,middle and inferior frontal lobes,the inferior parietal lobule and the superior temporal gyrus.But there was enhanced functional connectivity with the cerebellar posterior lobe,the occipital lobe,the medial temporal lobe,the precuneus and the calcarine.The results were significantly different between the two groups.Conclusion The functional connectivity pattern of the hippocampus is impaired in stroke patients with cognitive dysfunction.Reduced functional connectivity between brain regions may be one cause of cognitive dysfunction after stroke,and enhanced functional connectivity may be an appropriate compensatory mechanism.
