Clinical cohort study on renal pathological features and prognosis of type 2 diabetic kidney disease patients
10.3760/cma.j.issn.1001-7097.2014.09.002
- VernacularTitle:2型糖尿病肾病患者肾脏病理改变与预后的临床队列研究
- Author:
Xueyi WU
;
Hang LI
;
Yubing WEN
;
Qingyuan HUANG
;
Lin DUAN
;
Yan LI
;
Zengqi BI
- Publication Type:Journal Article
- Keywords:
Diabetic kidney disease,type 2;
Glomerulopathy,diabetic;
Renal disease,atypical diabetes-related
- From:
Chinese Journal of Nephrology
2014;30(9):650-655
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the relationship between renal pathological characteristics and clinical prognosis in type 2 diabetic kidney disease patients,and discuss predictive value of pathological type and indexes for renal function declining rate and related outcome events.Methods Ninety-two type 2 diabetes patients from PUMC Hospital (with macroalbuminuria and followed up no less than 6 months,excluding patients with non-diabetic renal disease) were divided into typical diabetic glomerulopathy group (DG,n=51) and atypical diabetes-related renal disease group(ADRD,n=41) according to renal pathological findings.A retrospective cohort study was performed to investigate renal pathological features and prognosis.Results Total of 29 renal outcome events and 12 death events occurred in DG group and none in ADRD group; the survival rate and kidney survival rate are different between two groups (P ＜ 0.05); DG group,thick GBM,severe vascular and tubular lesion are predicative indicators for renal outcome event; mesangial volume fraction is predicative indicator for renal outcome events independent of age and serum creatinine.Conclusions DG and ADRD patients have different prognosis and might undergo different pathophysiological mechanisms; renal pathological type and mesangial volume fraction could help predicting outcomes of type 2 diabetic nephropathy patients.
