Clinical significance of preoperative measurement of serum human epididymis protein 4, CA125 and CA19-9 in endometrial cancer patients

VernacularTitle:术前血清人附睾蛋白4、CA125及CA19-9水平在子宫内膜癌诊断中的价值
Author: Liuqing YE ; Jinwang DING ; Jiansong ZHOU ; Fan FAN ; Yuan JIN ; Wenhu CHEN
Publication Type:Journal Article
Keywords: Endometrial cancer; Tumor marker
From: Chinese Journal of General Practitioners 2014;13(8):695-697
CountryChina
Language:Chinese
Abstract: Preoperative serum specimens were collected from 249 endometrial cancers and 99 uterine leiomyomas and their concentrations of human epididymis protein 4 (HE4),CA 125 and CA 19-9 were detected.The indices of diagnostic evaluation were calculated.Preoperative serum concentrations of HE4,CA125 and CA19-9 in endometrial carcinoma group were significantly higher than those of control group.The areas under curve of HE4,CA125 and CA19-9 were 0.736,0.615 and 0.661 respectively and that of combiued markers was 0.774.At a 90％ specificity,the sensitivities for HE4,CA125,CA19-9 were 55.0％,26.9％ and 30.1％ while that of combined markers was 56.2％.HE4 is an ideal tumor marker for endometrial cancer and combined detection improves diagnostic rate.