Effects of two immunomodulatory agents for vitiligo and cellular immunity

VernacularTitle:两种免疫调节剂对白癜风患者细胞免疫的影响及疗效
Author: Xiaojuan LU ; Qilin LI ; Yonghua HUANG ; Mu NIU
Publication Type:Journal Article
Keywords: Vitiligo; Cellular immunity
From: Chinese Journal of General Practitioners 2014;13(8):684-686
CountryChina
Language:Chinese
Abstract: A total of 107 vitiligo patients were randomly divided into 3 groups.Group A received an intralesional injection of Bacillus Calmette-Guérin-polysaccharide nucleic acid (BCG-PSN) (n =34),group B Compound Glycyrrhizin Tablets (n =36) and group C both (n =37).Before treatment and 3 months after treatment,cellular immune function was detected for each group.Paired comparisons of 3 groups before and after treatment showed that CD4 +,CD4 +/CD8 + ratio increased (all P ＜ 0.05) and CD8 + decreased (P ＜0.05).After treatment,as compared with groups A and B,CD4 + increases (both P ＜ 0.05) and CD8 + decreased in group C (P ＜0.05).Group C had an efficiency rate of 91.9％ and it was higher than the other two groups (both P ＜ 0.05).An intralesional injection of BCG-PSN plus Compound Glycyrrhizin Tablets could improve immune function and treat vitiligo patients efficiently.