Treatment of frequently relapsing idiopathic nephrotic syndrome in children: cyclophosphamide vs mycophenolate mofetil

VernacularTitle:环磷酰胺与吗替麦考酚酯治疗儿童频复发肾病综合征的疗效比较
Author: Haiyun GENG ; Li CAO ; Chaoying CHEN
Publication Type:Journal Article
Keywords: Nephrotic syndrome; Immunosuppressive agents
From: Chinese Journal of General Practitioners 2014;13(8):682-684
CountryChina
Language:Chinese
Abstract: The clinical data of 43 children diagnosed as idiopathic nephrotic syndrome (INS) with frequent relapse and treated with cyclophosphamide (CTX) or mycophenolate mofetil (MMF) were retrospectively analyzed.In this series of patients 18 were treated with CTX and 25 were treated with MMF.After CTX therapy the relapse-free period was round 6.0 months,the relapse rate decreased from 4.8 episodes/y to 1.1 episodes/y(P ＜0.001)and prednisone dose was reduced from 30.0 mg/d to 15.0 mg/d (P =0.002).After MMF therapy the relapse-free period was also round 6.0 months,the relapse rate decreased from 4.8 episodes/y to 1.6 episodes/y(P ＜0.001)and the prednisone dose was reduced from 37.5 mg/d to 12.5 mg/d(P ＜ 0.001).There were no significant differences in relapse-free period,relapse rate and reduction of prednisone dose (P ＞ 0.05) between MMF and CTX groups.This retrospective study shows that both MMF and CTX are effective immunosuppressive agents for children with frequently relapsing INS,however,MMF is more convenient and safe to administrate,it may be proposed before CTX.