Plasma brain natriuretic peptide/N-terminal pro-brain natriuretic peptide ratio reflects the severity of pulmonary infection in patients with heart failure
10.3760/cma.j.issn.1671-7368.2014.07.020
- VernacularTitle:氨基末端B型利钠肽前体/B型利钠肽比值在心力衰竭合并肺部感染中的应用研究
- Author:
Hong ZHOU
;
Qiumei CAO
;
Yan FU
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Heart failure
- From:
Chinese Journal of General Practitioners
2014;13(7):587-589
- CountryChina
- Language:Chinese
-
Abstract:
Eighty two heart failure (HF) patients were enrolled in the study,including 52 cases with pulmonary infection (infectious group) and 30 cases without pulmonary infection (noninfectious group).Plasma brain natriuretic peptide (BNP),N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were measured and the correlation of plasma BNP,NT-proBNP and NT-proBNP/BNP with inflammatory markers (WBC count,CRP,PCT) and left ventricular ejection fraction (LVEF) was analyzed.Results show that NT-proBNP/BNP ratio in infectious group was significantly higher than that in noninfectious group (t =10.764,P ＜ 0.01).In infectious group,NT-proBNP/BNP was positively correlated with inflammation markers (P ＜ 0.01),but not with LVEF (P ＞ 0.05) ; NT-proBNP and BNP levels were not correlated with inflammation markers and LVEF (P ＞ 0.05).In noninfectious group,NT-proBNP/BNP was not correlated with inflammation markers and LVEF (P ＞ 0.05),NT-proBNP and BNP were positively correlated with CRP and negatively correlated with LVEF (all P ＜ 0.01),not correlated with WBC count or PCT (P ＞ 0.05).Multiple linear regression analysis showed that NT-proBNP/BNP ratio had positive correlation with CRP in infectious group.The results reveal that in heart failure patients complicated with pulmonary infection,neither NT-proBNP nor BNP reflects the severity of heart failure or infection; but the NT-proBNP/BNP ratio can indicate the severity of infection independently.
