Neurotoxicity preventive effect of oxaliplatin with lipoic acid plus sodium potassium magnesium calcium and glucose injection
10.3760/cma.j.issn.1671-7368.2014.07.018
- VernacularTitle:硫辛酸联合钠钾镁钙葡萄糖注射液预防奥沙利铂所致神经毒性的临床疗效
- Author:
Ran LYU
;
Yongjie LI
;
Qingliang FENG
;
Yu SUN
- Publication Type:Journal Article
- Keywords:
Neurotoxicity;
Oxaliplatin
- From:
Chinese Journal of General Practitioners
2014;13(7):583-584
- CountryChina
- Language:Chinese
-
Abstract:
A total of 218 patients on chemotherapeutic regimens containing oxaliplatin were randomly divided into experimental (n =120) and control (n =98) groups.The experimental group received an intravenous infusion of lipoic acid plus sodium potassium magnesium calcium and glucose injection.The control group had only normal saline.Overall incidence of neurotoxicity and toxicity grade of peripheral nerve were observed after 4,8 and 12 cycles.Those with neurotoxic symptoms were followed up for 1 year.No significantly statistical difference existed in the incidence of peripheral neurotoxicity after 4,8 cycles (P ＞0.05).After 12 cycles,31 patients in the experimental group had an onset of neurotoxicity of grade3 (n=8,6.7％) &grade4 (n=0) versus21 cases of grade3 (n=21,21.4％) and grade4 (n=5,5.1％) in the control group.Statistically significant differences existed between grades 3 and 4 neurotoxicity (P ＜0.05).After 1 year of follow-up,the incidence of grade 1 of neurotoxicity was 2.5％ (n =3) in the experimental group versus 23.7％ (n =9) in the control group.And the inter-group difference was statistically significant (P ＜ 0.05).Lipoic acid plus sodium potassium magnesium,calcium and glucose injection can effectively prevent the occurrences of acute and chronic peripheral neurotoxicity associated with oxaliplatin.
