Efficacy of oxycodone hydrochloride for prevention of fentanyl-induced cough during induction of anesthesia

VernacularTitle:盐酸羟考酮预防麻醉诱导中芬太尼诱发患者咳嗽的效果
Author: Zuolei TANG ; Wei WU
Publication Type:Journal Article
Keywords: Oxycodone; Fentanyl; Cough
From: Chinese Journal of Anesthesiology 2014;34(6):668-669
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy of oxycodone hydrochloride for prevention of fentanylinduced cough during induction of anesthesia in patients.Methods One hundred patients,aged 18-64 yr,weighing 45-74 kg,of ASA physical status Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were randomly divided into 2 groups with 50 cases in each group:control group (group C) and oxycodone hydrochloride group (group O).In C and O groups,normal saline 5 ml and oxycodone hydrochloride injection 0.1 mg/kg (in 5 ml normal saline) were injected,respectively,5 min later fentanyl 3 μg/kg was injected intravenously over 5 s,and 2 min later other drugs for induction of anesthesia were given.The development and intensity of cough were observed within 2 min after fentanyl injection.Results Compared with group C,the incidence of cough was significantly decreased and the intensity of coughing was mitigated in group O.Conclusion Intravenous oxycodone hydrochloride 0.1 mg/kg can decrease the development and intensity of fentanyl-induced cough during induction of anesthesia in patients.