Effect of sleep dysfunction on sedation induced by propofol in patients undergoing radical mastectomy

VernacularTitle:睡眠功能障碍因素对乳腺癌根治术患者异丙酚镇静效应的影响
Author: Juntao TAN ; Hongmeng XU ; Yong WANG ; Li JIA ; Yuying XING ; Dongjie QIU ; Zixian SONG
Publication Type:Journal Article
Keywords: Sleep disorders; Propofol; Piperidines
From: Chinese Journal of Anesthesiology 2014;34(6):661-662
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of sleep dysfunction on sedation induced by propofol in the patients undergoing radical mastectomy.Methods One hundred breast cancer patients,aged 25-60 yr,with body mass index of 19-23 kg/m2,of ASA physical status Ⅰ or Ⅱ,scheduled for elective modified radical mastectomy,were randomly divided into 2 groups according to sleep quality.The patients with global Pittsburgh Sleep Quality Index (PSQI) score ≤7 served as regular sleep quality group (Ⅰ group,n =59).The patients with global PSQI score ＞ 7 served as sleep dysfunction group (group Ⅱ,n =41).Anesthesia was induced with propofol given by target-controlled infusion (target plasma concentration of 3.5 μg/ml),and then with remifentanil 4 μg/kg and rocuronium 0.6 mg/kg after loss of consciousness.The consumption of propofol at loss of consciousness was recorded.Results Compared with group Ⅰ,the consumption of propofol at loss of consciousness was significantly decreased in group Ⅱ.Conclusion Sleep dysfunction can enhance propofol-induced sedation in the patients undergoing radical mastectomy.