Effects of different doses of dexmedetomidine on anterograde amnesia of propofol in patients undergoing gynecological surgery
10.3760/cma.j.issn.0254-1416.2014.05.003
- VernacularTitle:不同剂量右美托咪定对妇科手术患者异丙酚顺行性遗忘作用的影响
- Author:
Wei ZHANG
;
Xiaoyu MAO
;
Wei ZHANG
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Propofol;
Amnesia,anterograde
- From:
Chinese Journal of Anesthesiology
2014;34(5):533-536
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of different doses of dexmedetomidine on the anterograde amnesia of propofol in the patients undergoing gynecological surgery.Methods Sixty patients,aged 20-50 yr,with body mass index of 18-25 kg/m2,of ASA physical status Ⅰ or Ⅱ,scheduled for elective laparoscopic total hysterectomy,were randomly divided into 3 groups (n =20 each) using a random number table:propofol group (group C),low-dose dexmedetomidine combined with propofol group (group D1) and high-dose dexmedetomidine combined with propofol group (group D2).Dexmedetomidine 0.2 and 0.4 mg/kg were infused intravenously over 15 min in D1 and D2 groups,respectively.Target-controlled infusion of propofol was then started at an initial target plasma concentration (Cp) of 0.5 μg/ml.The Cp increased to 0.9,1.3,1.7 and 2.1 μg/ml in turn and maintained at each level for 3 min.After entering the operating room (baseline),at the end of dexmedetomidine infusion,and when Cp was maintained at each level for 3 min after being increased to 0.9,1.3,1.7 and 2.μg/ml in turn,and amnestic test and OAA/S score were performed.The Cp of propofol and BIS value were calculated when the amnestic rate reached 95 ％.The development of hypotension,bradycardia,respiratory depression,and upper airway obstruction was also recorded.Results Compared with group C,the amnestic rate was increased,the Cp of propofol and incidence of respiratory depression were decreased when the amnestic rate reached 95％,BIS value was increased (P ＜ 0.05),and no significant change was found in the incidence of the other adverse events in D1 and D2 groups (P ＞ 0.05).Compared with group D1,the amnesia rate was increased,the Cp of propofol was decreased and the BIS value was increased when the amnestic rate reached 95 ％ in group D2 (P ＜ 0.05),and no significant change was found in the incidence of the other adverse events in D1 and D2 groups (P ＞ 0.05).Conclusion The optimum dose of dexmedetomidine enhancing the anterograde amnesia of propofol is 0.4 μg/kg in the patients undergoing gynecological surgery.
