Expression and significance of p63, aromatase P450 and steroidogenic factor-1 in endometrial polyp
10.3760/cma.j.issn.0529-567x.2014.08.010
- VernacularTitle:p63蛋白、芳香酶P450及类固醇生成因子1在子宫内膜息肉中的表达及意义
- Author:
Tingting SU
;
Long SUI
- Publication Type:Journal Article
- Keywords:
Polyps;
Uterine diseases;
Aromatase;
Steroidogenic factor 1;
Transcription factors;
Tumor suppressor proteins
- From:
Chinese Journal of Obstetrics and Gynecology
2014;49(8):604-608
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and signification of p63,aromatase P450 (P450arom) and steroidogenic factor-1 (SF-1) in endometrial polyp,and to explore its role in the pathogenesis of endometrial polyp.Methods Specimen were collected from hysteroscopic resection,pathologically confirmed endometrial polyp specimens of 30 cases of endometrial polyp and the adjoining endometrium around endometrial polyp in 20 cases,endometrial tissue of normal control group of 25 patients.Immunohistochemistry SP method and real-time PCR technology were used to detect the three groups in the expression of p63,P450arom and SF-1 protein and gene.Results P450arom gene (0.274±0.082) and protein (1.2± 1.1) expression in endometrial polyp was significantly higher than the adjoining endometrium and normal endometrium (P＜0.05); the expression of SF-1 protein (1.1 ±0.8) and p63 protein (0.8±0.5) were also higher in the endometrial polyp than the other two control groups (P＜0.05); while the expression of SF-1 mRNA (0.105±0.049 versus 0.053±0.043) and p63 mRNA (0.261±0.052 versus 0.180± 0.018) in endometrial polyp had no significant difference between endometrial polyp and the adjoining endometrial (P＞0.05).Conclusion p63,P450arom and SF-1 may play a role in the formation of endometrial polyp.
