Evaluation of the impact of aldosterone in cardiac remodeling after myocardial infarction by high-frequency ultrasound
10.3760/cma.j.issn.1004-4477.2014.07.021
- VernacularTitle:高频超声评价醛固酮在心肌梗死中致心肌损伤的作用
- Author:
Ye ZHU
;
Ming CHEN
;
Yuhui ZHANG
;
Yi LIU
;
Lianghua XIA
;
Min XU
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Myocardial infarction;
Aldosterone
- From:
Chinese Journal of Ultrasonography
2014;23(7):618-622
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of high-frequency ultrasound in diagnosing the early reduced function of mice and to make sure the impact of aldosterone in cardiac remodeling after myocardial infarction.Methods Twenty aldosterone silence mice were selected as the experimental group and 20 healthy wild-type mice as the control.Animal models of acute myocardial infarction (AMI) were established by the method of the left anterior descending artery ligation.Cardiac function was measured by highfrequency echocardiography before and 2 weeks,4 weeks,6 weeks after AMI.Produce biopsy and Masson staining in both the experimental and the control groups were made post 6 weeks after AMI.Results ①Left ventricular long axis view and various short-axis views of mice could be clearly displayed by high-frequency echocardiography,and accurate measurements of the cardiac function could be obtained.② Compared with that in the control,left ventricular ejection fraction progressed more gradually in the experimental group than the control group (35.81 ± 2.88 vs 29.10 ± 4.50 at 6 weeks after AMI,P ＜0.05).Conclusions Blocked aldosterone may play a positive effect in reducing the myocardial injury.
