The influence factors of non-responsiveness and low-responsiveness to hepatitis B vaccine of infants born to hepatitis B surface antigen positive mothers
10.3760/cma.j.issn.1000-6680.2014.08.003
- VernacularTitle:乙型肝炎表面抗原阳性母亲所产婴儿对乙型肝炎疫苗无或低应答的影响因素
- Author:
Jian GUO
;
Yi GAO
;
Suping WANG
;
Zhen GUO
;
Linrui ZHANG
;
Bo WANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B vaccines;
Infant;
Intrauterine transmission
- From:
Chinese Journal of Infectious Diseases
2014;32(8):460-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence factors of non-responsiveness and lowresponsiveness to hepatitis B vaccine of infants born to hepatitis 1 surface antigen (HBsAg) positive mothers.Methods A total of 219 HBsAg positive mothers and their full-term neonates were selected from July 2011 to December 2012 in the Third People's Hospital of Taiyuan.Serologic hepatitis B virus (HBV) markers and HBV DNA load of mothers and their neonates were determined.Neonates were followed up for 12 months to observe the effect of HBV intrauterine infection,hepatitis B e antigen (HBeAg) status,sex,delivery mode,feeding option and suffering from infectious disease during followup period on the immune response to hepatitis B vaccine.Chi-square test was used in univariate analyses and unconditional Logistical regression was used in multivariate analyses.Results There were 16 cases of non-responsiveness and 33 cases of low-responsiveness in all 219 neonates.The rate of non-responsiveness and low-responsiveness was 22.37 ％.In univariate analyses,neonatal HBeAg positivity (x2 =4.895,P=0.027),natural birth (x2 =5.210,P=0.022),suffering from infectious diseases during follow-up period (x2 =4.329,P=0.037) were significantly associated with non-responsiveness and low-responsiveness.There was no relationship between mother HBeAg positivity and the level of response to hepatitis B vaccine.In multivariate analyses,natural birth (OR=2.022,95 ％CI:1.045-3.914) and suffering from infectious diseases (OR=2.324,95 ％ CI:1.058-5.103) were associated with non-responsiveness and low-responsiveness.Conclusion Infants born to HBsAg positive mothers with natural birth or suffering from infectious diseases during follow-up period are more likely to be non-responsiveness and lowresponsiveness to hepatitis B vaccine.
