Amplitude of low frequency fluctuation in first-episode depression and its relationship with the separate symptom clusters: a resting-state fMRI study
10.3760/cma.j.issn.1674-6554.2014.08.001
- VernacularTitle:首发抑郁症患者脑区低频振幅特征与症状群的相关性
- Author:
Rui YAN
;
Zhijian YAO
;
Hao TANG
;
Maobin WEI
;
Jianhuai CHEN
;
Lingling HUA
;
Qing LU
- Publication Type:Journal Article
- Keywords:
Depression;
Resting-state;
Amplitude of low frequency fluctuation;
Clinical symptom
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2014;23(8):673-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between energy feature of the spontaneous neural activity and separate symptom clusters in first-episode depression.Methods 22 first-episode depression patients and 26 age-,gender-matched healthy controls were scanned with 3.0 T MRI Scanner.The t-test was employed to compare the difference of amplitude of low frequency fluctuation (ALFF) between the two groups,and the correlation analyses were conducted between ALFF of brain regions with significant difference and the severity of depressive symptoms clusters.Results Compared with healthy group,the depression group showed significantly increased ALFF in the right middle frontal gyrus (9,45,-6; K =18) and the bilateral fusiform gyrus (-34,-19,-12; K =37 and 30,-33,-18 ; K =31,respectively),and decreased ALFF in the left precuneus (0,-72,42; K =19) (P＜0.05,corrected by Alphasim).The ALFF of the the right middle frontal gyrus,the right fusiform gyrus,and the left precuneus were negative correlated with the scores of weight factor,retardation factor and sleep disturbance factor (r=-0.494,P=0.019; r=-0.486,P=0.022 and r=-0.484,P=0.023,respectively).Conclusion Abnormal energy feature of the spontaneous neural activity may be associated with severity of specific depressive symptoms clusters in first-episode depression patients during resting-state.
