Meta-analysis on the trace element contents in plasma and serum of cases with major depression

VernacularTitle:抑郁障碍患者血微量元素的Meta分析
Author: Tao LIU ; Shuming ZHONG ; Xiaoxiao LIAO ; Yanbin JIA
Publication Type:Journal Article
Keywords: Major depression; Trace elements; Meta-analysis
From: Chinese Journal of Behavioral Medicine and Brain Science 2014;23(7):627-631
CountryChina
Language:Chinese
Abstract: Objective To estimate the concentrations of trace element contents in plasma and serum of cases with major depression.Methods The search for all the related literatures in CBMDisc,CNKI,VIP,ScienceDirect,Medline and so on has been made.Selection criteria:examination of plasma and serum trace elements in patients with major depression and control group.Data collection and analysis:a quantitative meta-analysis was carried out by two reviewers using information based on inclusion and exclusion criteria from all papers available.Results 24 studies met inclusion criteria,all with scores of 4 or more.Zn concentration in plasma and serum of patients with major depression significantly decreased compared with that in healthy people by 2.35 mol/L,95％ CI (-2.94,-1.75) (P＜0.01).The concentration of Cu and Fe had no significant difference between the two groups (P＞ 0.05).Conclusion There were abnormal trace elements in the patients with major depression,Zn decreased,Cu and Fe mainly appeared as an unbalanced state.It is necessary to carry out more extensive research and in-depth exploration.