Early enteral nutrition versus parenteral nutrition for patients with acute pancreatitis: a meta-analysis
10.3760/cma.j.issn.1674-635X.2014.04.007
- VernacularTitle:早期肠内外营养对急性胰腺炎预后的Meta分析
- Author:
Dan ZHANG
;
Hua HUANG
;
Jing XU
;
Feng GAO
;
Yang YANG
- Publication Type:Journal Article
- Keywords:
Acute pancreatitis;
Enteral nutrition;
Parenteral nutrition;
Meta-analysis
- From:
Chinese Journal of Clinical Nutrition
2014;22(4):225-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the impacts of early enteral nutrition (EN) and parenteral nutrition (PN) on the prognosis of acute pancreatitis.Method By searching relevant literature between January 1996 and August 2013 in Chinese and English databases including Wanfang,VIP,CNKI,PubMed,the Cochrane Library,CBM,and EMABSE,we compared the prognosis of acute pancreatitis after EN or PN in terms of casefatality rate,infections,multiple organ failure,and other complications.Result Compared with PN,early EN significantly reduced the case-fatality rate [OR =0.37,95％ CI (0.23,0.58),P ＜ 0.000 1],decreased the infection rate [OR =0.24,95％ CI (0.15,0.39),P ＜0.000 01],shortened hospital stay [MD =-9.87,95％ CI (-10.84,-8.89),P ＜ 0.000 01],and reduced complications [OR =0.26,95％ CI (0.12,0.58),P =0.001 0] in patients with acute pancreatitis,although the incident of multi-organ failure showed no significant difference [OR =0.35,95％ CI (0.10,1.19),P =0.09].Conclusions For patients with acute pancreatitis,early EN is superior than PN in terms of case-fatality rate,infection rate,hospital stay,and complications.Therefore,it should be applied in such patients whenever condition allows.
