Body composition analysis in transverse aorta constriction mice
10.3760/cma.j.issn.1674-635X.2014.03.012
- VernacularTitle:主动脉弓狭窄小鼠体成分分析
- Author:
Qingchun LIU
;
Desheng ZHU
;
Jinghao LIU
;
Yu LEI
;
Jun LI
- Publication Type:Journal Article
- Keywords:
Body composition analysis;
Transverse aorta constriction;
Gene chip
- From:
Chinese Journal of Clinical Nutrition
2014;22(3):183-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of lipid metabolism during adaptive heart failure.Method The transverse aorta constriction mouse models established by minimal invasive surgery technique were evaluated for early small changes of body composition by EchoMRITM whole body composition analysis,and the different gene expression was analyzed by whole genome expression microarray.Results Three weeks after the surgery,the fat composition,in the mouse models were (0.49 ± 0.13) g,which was significantly lower than that in the sham surgery group [(0.81-±0.14) g] (P =0.002).The expression of the natriuretic peptide type A significantly increased over time (R2 =0.939,P =0.005).In addition,the levels of fatty acid desaturase,long-chain fatty acid elongase 5,and N-acylsphingosine amidohydrolase increased,and the levels of acyl-coenzyme A dehydrogenase,muscle glycogen phosphorylase,and pyruvate dehydrogenase kinase decreased,showing increased fat mobilization and decreased carbohydrate utilization.Conclusions Surgery for transverse aorta constriction can cause complex metablic changes in heart.The activated lipid mobilization maybe lead to the low body fat composition.
