The combined detection and clinical significance of autoantibodies in patients with autoimmune hepatitis
10.3760/cma.j.issn.1673-4904.2014.25.018
- VernacularTitle:自身免疫性肝炎自身抗体联合检测的临床意义
- Author:
Li WANG
;
Ting XU
;
Jianping CHEN
- Publication Type:Journal Article
- Keywords:
Autoimmune hepatitis;
Autoantibodies;
Combined detection
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(25):49-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the combined detection and clinical significance of autoantibodies in patients with autoimmune hepatitis (AIH).Methods Collected 1 593 cases of patients with hepatic dysfunction,33 cases were diagnosed as AIH.Serum anti-smooth muscle antibody (ASMA),soluble liver antigen/liver pancreas (SLA/LP) antibody,liver kidney microsomal-1 (LKM-1) antibody,hepatic cell solute antigen type-1 (LC-1) antibody,anti-mitochondrial antibody (AMA),antinuclear envelope glycoprotein (gp) 210 antibody,anti sp100 antibody,antinuclear antibody(ANA),anti extractable nuclear antigen antibody spectrum (ENA) and anti neutrophil cytoplasmic antibody (ANCA) were measured in patients.The clinical manifestations were recorded.Results In 33 patients with AIH,the positive rate of ANA was 81.8％(27/33).For the diagnosis of AIH,the sensitivity/specificity rate of ASMA were 57.6％(19/33)/97.6％(161/165).The sensitivity/specificity rate of LKM-1 antibody were 12.1％(4/33) /91.5％(151/165).The sensitivity/specificity rate of SLA/LP antibody were 6.1％(2/33)/99.4％(164/165).The sensitivity/specificity rate of anti LC-1 antibody were 9.1％ (3/33)/99.4％ (164/165).There were no antisp100 antibody and anti-gp210 antibody in AIH.Conclusion The diagnostic rate of AIH is improved by combined detection of autoantibodies.
