Clinical significance of interstitial chemotherapy applied in breast cancer
10.3760/cma.j.issn.1673-4904.2014.23.001
- VernacularTitle:间质化疗在乳腺癌术中应用的临床意义
- Author:
Hongjie SHAN
;
Jinbin NI
;
Can MA
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Mastectomy,modified radical;
Fluorouracil;
Interstitial chemotherapy
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(23):1-2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of interstitial chemotherapy applied in breast cancer.Methods Sixty breast cancer patients with modified radical mastectomy were divided into treatment group (40 cases) and control group (20 cases) according to whether using fluorouracil implants.The control group was given conventional treatment.In treatment group,distilled water washed the wound after conventional treatment,and fluorouracil implants (0.4 g) was placed below local tumor,between pectoralis major and pectoralis minor,below 0.5 cm axillary vessel.The bone marrow suppression,liver and renal function,gastrointestinal reaction,skin flap necrosis,subcutaeous hydrops,local recurrence were observed in the 2 groups.Results There were no significant differences in the rates of bone marrow suppression,liver and renal function abnormal,skin flap necrosis,subcutaeous hydrops and gastrointestinal reaction between treatment group and control group (P ＞ 0.05).The rate of local recurrence in treatment group was significantly lower than that in control group [0 vs.20.0％ (4/20)],there was statistical difference (P ＜0.05).Conclusion Intraoperative application of fluorouracil implants is safe and effective in modified radical mastectomy of breast cancer.
