A Case of Isolated Leptomeningeal Carcinomatosis from Advanced Gastric Cancer.
- Author:
Jung Geun JI
1
;
Joo Won CHUNG
;
Seung Woo NAM
;
Seung Kyu CHOI
;
Dong Won LEE
;
Dae In KIM
;
Byung Gwan JEON
;
Yun Jae SHIN
Author Information
- Publication Type:Case Report
- Keywords: Gastric cancer; Leptomeningeal carcinomatosis; Neurologic manifestations
- MeSH: Abdomen; Aged, 80 and over; Biopsy; Brain; Carcinoma, Signet Ring Cell; Cerebrospinal Fluid; Consciousness; Diagnosis; Female; Headache; Humans; Magnetic Resonance Imaging; Melena; Meningeal Carcinomatosis*; Neoplasm Metastasis; Neurologic Manifestations; Pelvis; Spinal Puncture; Stomach; Stomach Neoplasms*; Vomiting
- From:The Korean Journal of Gastroenterology 2016;68(2):93-98
- CountryRepublic of Korea
- Language:Korean
- Abstract: Leptomeningeal carcinomatosis (LMC) is rare metastatic form of gastric cancer. Most cases are diagnosed in the final stage after multiple distant metastasis. An 84-year-old woman was admitted with melena, headache and vomiting. Esophagogastro-duodenoscopy showed an ulceroinfiltrating lesion at the stomach (Borrmann class III), and biopsy revealed a signet ring cell carcinoma. The abdominal-pelvic CT showed no evidence of metastasis. A sudden decrease of consciousness was noted, but the brain CT showed no active lesion while the brain MRI revealed enhancement of leptomeninges. A lumbar puncture was performed and the cerebrospinal fluid study revealed malignant neoplastic cells. With family consent, no further evaluation and treatment were administered and she died six weeks after the diagnosis of gastric cancer. We report an extremely rare case of a patient who initially presented with neurologic symptoms, and was diagnosed LMC from advanced gastric cancer without any evidence of metastasis in abdomen and pelvis.
