Role of adhesion molecule CD44 in respiratory syncytial virus infection induced bronchiolitis
10.3760/cma.j.issn.1673-4904.2014.27.009
- VernacularTitle:黏附分子CD44在呼吸道合胞病毒感染致毛细支气管炎中的作用
- Author:
Huiru YI
;
Xingyu LUO
;
Li YIN
;
Weimin CHEN
- Publication Type:Journal Article
- Keywords:
Bronchiolitis;
Respiratory syncytial virus;
Antigens,CD44
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(27):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role ot adhesion molecule CD44 in respiratory syncytial virus (RSV) infection induced bronchiolitis.Methods Thirty-six children with RSV infection induced bronchiolitis (infection A group),34 children with only RSV infection (infection B group) and 40 healthy children (control group) were selected.The proportion of peripheral blood CD44+ cell was determined by flow cytometry.The levels of peripheral blood interferon (IFN)-γ,interleukin (IL)-4,IL-10 and IL-12 were determined by enzyme-linked immunosorbent assay.Results The expression of CD44 and the level of IL-4 in peripheral blood in infection A group were significantly higher than those in infection B group and control group,there were statistical differences (P ＜ 0.05).The level of IFN-γ in peripheral blood in infection A group was significantly lower than that in infection B group and control group,there were statistical differences (P ＜0.05).The levels of IL-12 in peripheral blood in infection A group and infection B group were significantly lower than that in control group,there were statistical differences (P ＜ 0.05).There were no statistical differences in the level of IL-10 in peripheral blood among the 3 groups (P ＞ 0.05).In the children with RSV infection,the expression of CD44 in peripheral blood was positively correlated with the level of IL-4 (r =0.798,P ＜ 0.05),the level of IL-12 was negatively correlated with the level of IL-4 (r =-0.186,P ＜0.05).Conclusion The expression of adhesion molecule CD44 may play a role in the RSV infection induced bronchiolitis,and the high expression of CD44 in children with RSV infection may increase the susceptibility to bronchiolitis.
