The analysis of blood fat and high sensitive-C reactive protein in patients with subclinical hypothyroidism
10.3760/cma.j.issn.1673-4904.2014.19.007
- VernacularTitle:亚临床甲状腺功能减退症患者血脂及超敏C反应蛋白变化分析
- Author:
Dongmei YIN
;
Min XU
;
Hui TIAN
- Publication Type:Journal Article
- Keywords:
Hypothyroidism;
Dyslipidemias;
C-reactive protein;
Atherosclerosis
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(19):19-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the change and clinical significance of blood lipid and high sensitive-C reactive protein (hs-CRP) in patients with subclinical hypothyroidism.Methods Fifty patients with subclinical hypothyroidism were selected as observation group,and 50 health people with the same gender and age were selected as control group.The blood lipid and hs-CRP levels in the two groups were measured and compared.Results The total cholesterol (TC),triacylglycerol (TG),and low density lipoprotein cholesterol (LDL-C) in observation group were significantly higher than those in control group [(5.20 ±0.84) mmol/L vs.(4.79 ±0.80) mmol/L,(2.21 ±0.97) mmol/L vs.(1.78 ±0.60) mmol/L,(3.25 ±0.65) mmol/L vs.(2.83 ±0.51) mmol/L],high density lipoprotein cholesterol (HDL-C) was significantly lower than that in control group [(1.18 ± 0.15) mmol/L vs.(1.28± 0.22) mmol/L],and there were statistical differences (P ＜ 0.05 or ＜ 0.01).The hs-CPR in observation group was significantly higher than that in control group [(4.2 ± 1.1) mg/L vs.(3.0 ± 0.8) mg/L],and there was statistical difference (P ＜0.01).Conclusions Subclinical hypothyroidism can cause increased TC,TG,LDL-C and hs-CRP and decreased HDL-C,which may accelerate atherosclerosis and cardiovascular disease.It is necessary to timely screen and treat the disease.
