Expression and significance of autoantibodies against angiotensin Ⅱ type 1 receptor in acute coronary syndrome
10.3760/cma.j.issn.1673-4904.2014.19.004
- VernacularTitle:血管紧张素Ⅱ1型受体自身抗体在急性冠状动脉综合征中的表达及意义
- Author:
Yongqing CHEN
;
Mingxu ZHANG
;
Lihua LIU
;
Tao DANG
;
Zhidong BAI
;
Yu WANG
;
Peng ZHANG
- Publication Type:Journal Article
- Keywords:
Receptor,angiotensin,type 1;
Autoantibodies;
Acute coronary syndrome
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(19):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the expression of autoantibodies against angiotensin Ⅱ type 1 receptor (AT1-AAs),monocyte chemoattractant protein-1 (MCP-1) and high-sensitivity C-reactive protein (hs-CRP) in patients of acute coronary syndrome (ACS),and study the role of AT1-AAs in plaque stability and pathogenesis of ACS.Methods Sixty patients with ACS were selected as ACS group,60 patients with stable angina pectoris (SAP) were selected as SAP group,and 60 healthy people were selected as control groups.The epitopes of the second extracellular loop of angiotensin Ⅱ type 1 receptor (165-191) were synthesized and used as antigen to screen the serum autoantibodies by enzyme-linked immunosorbent assay (ELISA).The peripheral blood levels of MCP-1 and hs-CRP were also evaluated.Results The positive rates of AT1-AAs in ACS group,SAP group and control group were 45.0％(27/60),21.7％(13/60) and 5.0％(3/60),respectively.The positive rates of AT1-AAs in ACS group and SAP group were significantly higher than those in control group,the positive rate of AT1-AAs in ACS group was significantly higher than that in SAP group,and there were statistical differences (P ＜ 0.01).The MCP-1 and hs-CRP levels in ACS group and SAP group were significantly higher than those in control group,the MCP-1 and hs-CRP levels in ACS group were significantly higher than those in SAP group,and there were statistical differences (P ＜ 0.01).The MCP-1 and hs-CRP levels in AT1-AAs positive patients in ACS group and SAP group were significantly higher than those in AT1-AAs negative patients,and there were statistical differences (P ＜0.01).Conclusions AT1-AAs may play an important role in the pathogenesis of ACS.Inducing the expression of inflammatory factor through AT1-AAs maybe an important mechanism for plaque instability.
