Influence of ozone therapy on high-sensitivity C-reactive protein and matrix metalloproteinases-3 in synovial fluid of patients with knee osteoarthritis
10.3760/cma.j.issn.1673-4904.2014.26.016
- VernacularTitle:臭氧治疗对膝骨性关节炎关节滑液中高敏C反应蛋白和基质金属蛋白酶3的影响
- Author:
Ping LUO
;
Yuhua XIANG
;
Junhua WANG
;
Youhui LI
- Publication Type:Journal Article
- Keywords:
Osteoarthritis;
C-reactive protein;
Matrix metalloproteinase-3;
Ozone
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(26):43-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of ozone therapy on high-sensitivity C-reactive protein (hs-CRP) and matrix metalloproteinases-3 (MMP-3) in synovial fluid of patients with knee osteoarthritis,and to investigate the possible mechanism.Methods Sixty-two patients with knee osteoarthritis were divided into observation group and control group by random digits table method with 31 cases each.The patients of observation group were treated with ozone,while the patients of control group were treated with hyaluronic acid once a week for 5 weeks.The efficacy was evaluated and the level of hs-CRP and MMP-3 in synovial fluid were detected before and after treatment.Results The total effective rate in observation group was 100.00％ (31/31),significantly higher than that in control group [87.10％ (27/31)],and there was significant difference (x2 =4.28,P ＜ 0.05).After treatment,the level of hs-CRP and MMP-3 in observation group was (6.68 ±2.15) mg/L,(69.84 ± 16.97) μ g/L,significantly lower than that in control group [(8.72 ± 2.39) mg/L,(85.43 ± 19.52) tμ g/L],and there was significant difference (t =3.53,3.36,P ＜ 0.01).Conclusion There is significant effect of ozone therapy of patients with knee osteoarthritis,its mechanism may be reducing the level of MMP-3 and inhibiting inflammatory reaction.
