Clinical research of restructuring human brain natriuretic peptide treatment of in heart failure associated with severe acute myocarditis
10.3760/cma.j.issn.1673-4904.2014.25.021
- VernacularTitle:重症急性心肌炎伴心力衰竭患者应用重组人脑利钠肽治疗的临床研究
- Author:
Hongyun WANG
;
Yan CHENG
;
Liang QIN
- Publication Type:Journal Article
- Keywords:
Heart failure;
Severe acute myocarditis;
Restructuring the brain natriuretic peptide
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(25):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical effect of restructuring human brain natriuretic peptide in treatment of heart failure associated with severe acute myocarditis.Methods Fifty cases of heart failure associated with severe acute myocarditis were divided into experimental group and control group according random number table method,each group 25 cases.The patients in control group were given conventional treatment,and the patients in experimental group were given restructuring human brain natriuretic peptide on the basis of conventional treatment.The clinical effects of two groups were observed.Results The level of N terminal brain natriuretic peptide,left ventricular ejection fraction,urine volume,creatinine in two groups had no significant difference before treatment (P ＞ 0.05).After treatment,these index in experimental group were better than those in control group [(7 785 ± 432) ng/L vs.(10 022 ± 447) ng/L,(45.28 ± 2.67)％ vs.(41.34 ±3.11)％,(1 833 ±49) ml/24 h vs.(1 456 ±47) ml/24 h,(109.34 ± 10.77) μmol/L vs.(125.44 ± 11.00) μ mol/L] (P ＜ 0.05).The rate of clinical symptoms improving in experimental group was significantly higher than that in control group [71.4％ (55/77) vs.26.0％ (20/77)] (P ＜0.01).Conclusion Restructuring human brain natriuretic peptide with conventional treatment can effectively improve heart failure associated with severe clinical symptoms of acute myocarditis,improve the clinical therapeutic effect.
