Early assessment of the level of serum cystatin C to renal damage in patients with multiple myeloma

VernacularTitle:血清胱抑素C对多发性骨髓瘤肾损害的早期评估
Author: Lingling SUN ; Yanli MENG ; Guangyu SONG ; Jingjing HU ; Bin JI
Publication Type:Journal Article
Keywords: Multiple myeloma; Cystatin C; β2-microglobulin; Renal function
From: Chinese Journal of Postgraduates of Medicine 2014;37(25):56-58
CountryChina
Language:Chinese
Abstract: Objective According to the level of serum cystatin C (Cys-C)in patients with multiple myeloma (MM),to explore its significance of early assessment to renal damage.Methods To select 42 patients with MM(MM group) and 30 healthy subjects(control group),and measure serum Cys-C,creatinine (SCr) and β2-microglobulin (β2-MG).Results The level of serum Cys-C in MM group was significantly higher than that in control group [(2.34 ± 0.57) mg/L vs.(0.66 ± 0.12) mg/L],which increased with ISS stage[Ⅰ,Ⅱ,Ⅲ stage was(1.77 ± 0.38),(2.11 ± 0.46),(3.14-± 1.07) mg/L](P＜ 0.05).Cys-C and β 2-MG,renal function had a positive correlation (r =0.760,0.694,P ＜ 0.05).Conclusion The increasing of Cys-C in MM patients is related to impaired renal function and tumor burden,which can be used as an early assessment indicators.