The differential diagnostic value of detecting interferon-γ inducible protein 10, macrophage inflammatory protein-la and monocyte chemoattractant-1 in tuberculous and malignant pleural effusion
10.3760/cma.j.issn.1673-4904.2014.25.003
- VernacularTitle:趋化因子γ-干扰素诱导蛋白-10、巨噬细胞炎性蛋白-1α、单核细胞趋化因子-1对结核性和恶性胸腔积液鉴别诊断的价值分析
- Author:
Zhaoqiang REN
;
Xianghai WANG
;
Cunzhi LIN
;
Xinhong ZHU
;
Fei LIU
- Publication Type:Journal Article
- Keywords:
Pleural effusion;
Tuberculosis,pulmonary;
Neoplasm;
Chemokine
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(25):7-9
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the differential diagnostic value of interferon-γ inducible protein 10 (IP-10),macrophage inflammatory protein-1 α (MIP-1 α) and monocyte chemoattractant-1 (MCP-1) level in the tuberculous,malignant pleural effusion.Methods Enzyme-linked immunosorbent assay was used to detect the level of IP-10,MIP-1 α and MCP-1 in tuberculous pleural fluid (tuberculous pleural fluid group,43 cases) and malignant pleural fluid (malignant pleural fluid group,45 cases).The level of IP-10,MIP-1 α and MCP-1 and the significance were analyzed by ROC curve.Results The level of IP-10,MIP-1 α and MCP-1 were significantly higher in tuberculous pleural fluid group than those in malignant pleural fluid group,and there were significant differences(t =4.931,3.106,2.385 ; P =0.000,0.004,0.041).ROC curve analysis showed that the critical value of IP-10,MIP-1 α and MCP-1 in diagnosis of pleural effusion was respectively 1 589.73,213.50,1 452.63 ng/L.The sensitivity and specificity of IP-10,MIP-1 α and MCP-1 in pleural fluid were 68.8％,81.3％,87.5％ and 87.5％,68.8％,56.3％,respectively.Conclusion The level of IP-10,MIP-1 α and MCP-1 in tuberculous and malignant pleural fluid are significant for the early diagnosis and differential diagnosis.
