Clinical significance of plasma D-dimer, fibrinogen and fibrin/fibrinogen degradation product detection in patients with chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4904.2014.25.002
- VernacularTitle:慢性阻塞性肺疾病患者血浆D-二聚体、纤维蛋白原及纤维蛋白(原)降解产物检测的临床意义
- Author:
Jun CHEN
;
Bicheng HU
;
Tianpen CUI
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
D-dimer;
Fibrinogen;
Fibrin/fibrinogen degradation product
- From:
Chinese Journal of Postgraduates of Medicine
2014;37(25):5-6
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate clinical significance of plasma D-dimer (D-D),fibrinogen (FIB) and fibrin/fibrinogen degradation product (FDP) in patients with chronic obstructive pulmonary disease (COPD).Methods The level of plasma D-D,FIB and FDP in 150 patients with COPD and 80 healthy persons were detected,and compared.Results The level of plasma D-D,FIB and FDP in COPD patients were significantly higher than those in healthy persons[(2.16 ± 0.61) mg/L vs.(0.55 ± 0.04) mg/L,(5.88 ± 1.52) g/L vs.(3.12 ± 0.35) g/L,(7.18 ± 1.63) mg/L vs.(3.62 ± 1.55) mg/L],there were significant differences (P ＜ 0.01).Conclusion Monitoring the level of plasma D-D,FIB and FDP in COPD patients can provide reliable basis in hypercoagulable state and primary and secondary hyperfibrinolysis.
