The research on the different expression of matrix metalloproteinase-9 in cervical columnar ectopy and cervical intraepithelial neoplasia

VernacularTitle:基质金属蛋白酶9在宫颈柱状上皮异位及宫颈上皮内瘤变中不同表达的研究
Author: Wei YUAN ; Shujun CAO ; Liping GAO ; Daohua YANG ; Chengmin QIU
Publication Type:Journal Article
Keywords: Matrix metalloproteinase-9; Uterine cervical neoplasms; Cervical columnar ectopy
From: Chinese Journal of Postgraduates of Medicine 2014;37(24):12-14
CountryChina
Language:Chinese
Abstract: Objective To explore the different probability of carcinoma and the necessity of treatment in cervical columnar ectopy (CCE),normal smooth cervix and cervical intraepithelial neoplasia(CIN) by investigating the different expression of matrix metalloproteinase-9(MMP-9).Methods The expression of MMP-9 was detected by using immunohistochemical method in 30 cases of CCE,28 cases of CIN and 30 cases of normal smooth cervix from 2007 to 2012.Results The positive expression of MMP-9protein in CIN was 96.4％ (27/28),CCE was 23.3％ (7/30) and normal smooth cervix was 20.0％ (6/30)respectively.The positive expression of MMP-9 protein was higher in CIN than CCE and normal smooth cervix,the difference has statistical significance (P＜ 0.01),there was no significant difference between CCE and normal smooth cervix (P ＞ 0.05).Conclusions CCE,which was a physiological performance of cervical erosion,should not be overtreated.But the women of childbearing age should be routinely performed in cervical cancer screening.