A Case of Posttransplant Lymphoproliferative Disease Following Renal Transplantation in a Child.
- Author:
Won Kyoung JHANG
1
;
Hyewon HAHN
;
Mee Jeung LEE
;
Young Seo PARK
;
Thad T GHIM
Author Information
1. Department of Pediatrics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. yspark@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Posttransplant lymphoproliferative disease;
EBV;
Late-onset;
Malignant lymphoma;
Kidney transplantation
- MeSH:
Adolescent;
Bone Marrow;
Child*;
Drug Therapy;
Epstein-Barr Virus Infections;
Female;
Herpesvirus 4, Human;
Humans;
Kidney Transplantation*;
Lymphocytes;
Lymphoma;
Organ Transplantation;
Pseudolymphoma;
Sepsis;
Shock, Septic;
Transplants
- From:Journal of the Korean Society of Pediatric Nephrology
2003;7(2):245-252
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Posttransplant lymphoproliferative disease(PTLD) has emerged as a potential life-threatening complication of immunosuppressive therapy after organ transplantation. The occurrence of PTLD is usually associated with an Epstein-Barr virus(EBV) infection in patients who are treated by aggressive immunosuppressive therapy. PTLD is represented by diverse manifestations ranging from reactive lymphoid hyperplasia to high grade malignant lymphoma. This is a case report of a late PTLD in a child. The patient is a 14-year-old girl, who presented as malignant lymphoma 44 months after successful renal transplantation. There was no evidence of EBV infection. On bone marrow study, many neoplastic lymphoid cells were detected. Aggressive chemotherapy for PTLD had resulted in clinical remission. However the patient expired from uncontrolled sepsis and septic shock after 77 days.
