Expression of 5-HT2A receptor in brainstem affects the occurrence of central sleep apnea in Sprague-Dawley rat
10.3969/j.issn.1006-5725.2014.16.007
- VernacularTitle:Sprague-Dawley大鼠脑干5-HT2A受体表达与睡眠呼吸暂停的关系
- Author:
Tao ZHANG
;
Cheng ZHANG
;
Guangfa WANG
- Publication Type:Journal Article
- Keywords:
Respiratory central;
Sleep apnea syndromes;
5-HT2A receptor;
Respiratory control
- From:
The Journal of Practical Medicine
2014;(16):2543-2546
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlationship of 5-HT2A receptor expression in the brainstem and sleep apnea in Sprague-Dawley (SD)rat. Method PSG monitoring for sleep and sleep apneas scoring was performed in freely moving SD rats. The level of 5-HT2A protein in rat brainstem was detected by Western blot and the relationship of 5-HT2A level with sleep apneas was analyzed. Results Two types sleep apnea model were obtained in rats, one was post-sigh sleep apnea (PS) and the other was spontaneous apnea (SP). The sleep apnea index was negatively correlated with the amount of 5-HT2A receptor level in brainstem (r=0.672,P <0.001). The post-sigh sleep apnea index was negatively correlated with the amount of 5-HT2A level in brainstem (r=0.686, P<0.001). The NREM-PS index was also negatively correlated with the amount of 5-HT2A level in brainstem (r =0.663, P < 0.001),but the spontaneous apnea index was not correlated with the amount of 5-HT2A level in brainstem (P>0.05). Conclusion The expression of 5-HT2A receptor in brainstem was negatively correlated with the severity of post-sigh sleep apnea. This association implies that 5-HT 2A receptor plays a critical role in the respiratory network and is closely correlated with the occurrence of central sleep apneas.
