Impact of intra-arterial versus intravenous administration of epinephrine on the efficacy of CPR in mice
10.3969/j.issn.1006-5725.2014.16.010
- VernacularTitle:经动脉与经静脉注射肾上腺素对小鼠心肺复苏疗效的影响
- Author:
Weini GAN
;
Fengqing SONG
;
Lu XIE
;
Menghua CHEN
- Publication Type:Journal Article
- Keywords:
Cardiac arrest;
Cardiopulmonary resuscitation;
Epinephrine
- From:
The Journal of Practical Medicine
2014;(16):2555-2557
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the impact of intra-arterial versus intravenous administration of epinephr-ine on the efficacy CPR in mice. Methods Transoesophageal cardiac pacing was performed to induce cardiac arrest for 4 minitues in 20 Kunming male mice. The mice were then randomized to two groups (n = 10 in each group), and received epinephrine of 0.02 mg/kg via either carotid artery (IA-gro) or jugular vein (IV-gro) injection. Chest compression and ventilation were performed; and the rate of restoration of spontaneous circulation (ROSC) and survival time were recorded. CPR was stopped if spontaneous circulation was not restored within 10 minutes. Results There was no significant difference in the rates of ROSC between IA-gro and IV-gro (10/10 vs. 8/10, P>0.05), nor in the time of ROSC or survival time [51 ± 13 s vs. 62 ± 24 s; 8.5 (6.0, 17.0) h vs. 6.5 (2.8, 21.3) h, P > 0.05]. Conclusions Neither intra-arterial nor intravenous administration of epinephrine has no obvious impact on the efficacy of CPR in mice.
