Relation between apolipoproteinC3 (-482C>T) polymorphism and nonalcoholic fatty liver disease in the Han Chinese population
10.3969/j.issn.1006-5725.2014.16.013
- VernacularTitle:中国汉族人载脂蛋白C3（-482C＞T）多态性与非酒精性脂肪肝的关系
- Author:
Minrui LI
;
Shenghong ZHANG
;
Xianhua LIAO
;
Bihui ZHONG
- Publication Type:Journal Article
- Keywords:
Nonalcoholic fatty liver disease;
Insulin resistance;
ApolipoproteinC3 (-482C>T );
Polymorphism
- From:
The Journal of Practical Medicine
2014;(16):2566-2569
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relation between apolipoproteinC3 (-482C>T ) polymorphism and nonalcoholic fatty liver disease (NAFLD) and its clinical characteristics in the Han Chinese population. Methods Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and polyacrylamide gel electrophoresis(PAGE)were used to analyse the genotype of the apolipoproteinC3 (-482C>T) variants. Results No relation between the apolipopreoteinC3 (-482C>T) polymorphism and NAFLD was found. However, NAFLD patients carrying T allele were more susceptible to insulin resistant (IR), hypertension, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol (HDL) than homozygote CC genotype. Conclusion There was no relation between the apolipopreoteinC3 (-482C>T)polymorphism and NAFLD in Han Chinese population, but T-carriers were more susceptible to metabolic disorder.
