An analysis on risk factors of radiation-induced oral mucositis in patients with nasopharyngeal carcinoma

VernacularTitle:鼻咽癌患者放射性口腔炎的危险因素分析
Author: Xiaoxia ZHU ; Longhua CHEN ; Yilan CHAO
Publication Type:Journal Article
Keywords: Nasopharyngeal neoplasms; Radiation-induced oral mucositis; Risk factors; Leukopenia
From: The Journal of Practical Medicine 2014;(16):2583-2585
CountryChina
Language:Chinese
Abstract: Objective To investigate the risk factors of radiation-induced oral mucositis (ROM) and to provide evidence for the prevention of ROM. Methods The severity of ROM was observed and recorded in 56 patients with nasopharyngeal carcinoma. The association of the severity of mucositis with age , sex, clinical stage, concurrent chemoradiotherapy, white blood cell count,BMI index, smoking, alcohol intake, and history of diabetes were assessed by using multivariate logistic regression analysis. Results The severity of ROM was significantly associated with a decrease in leucocyte count (P<0.05), and it was not markedly correlated with the other eight factors (P>0.05). Conclusions Leukopenia was one of the risk factors for the development of ROM. In clinical pratice,leukopenia should be corrected in patients with bone marrow depression due to radiotherapy in a timely manner.