Prospective multicenter study on syndrome differentiation-based treatment with traditional Chinese medicine for Chronic Kidney Disease (CKD3-4)
10.3969/j.issn.1006-5725.2014.16.044
- VernacularTitle:中成药辨证论治慢性肾脏病3-4期的多中心前瞻性临床研究
- Author:
Yuan MENG
;
Shengrong ZHANG
;
Baoli LIU
;
Jing LI
;
Yiwen ZHAO
;
Yu WANG
;
Jing ZHAO
;
Wenjing ZHAO
;
Nan GE
;
Yanfang YANG
;
Yang LIU
;
Jianwei REN
;
Hong CHENG
;
Jianping LIU
- Publication Type:Journal Article
- Keywords:
Chronic Kidney Disease (CKD3-4);
Chinese Traditional Patent Medicine;
Syndrome differentiation-based treatment
- From:
The Journal of Practical Medicine
2014;(16):2658-2662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical curative effect of syndrome differentiation-based treatment with traditional Chinese medicine on patient with Chronic Kidney Disease (CKD3-4). Method According to prospective multicenter randomized controlled study which was applied to the patients with CKD3-4 , the total of 339 patients were divided into two groups. To one group as standard including 167 patients ,the other including 172 patients. Chinese Traditional Patent Medicine single or combined-prescription oral treatment according to syndrome differentiation-based treatment was employed. To the other group as reference , Chinese Traditional Patent Medicine oral treatment according to experienced rule was applied. The clinical curative effect results were obtained after a 24 weeks-treatment. Result The Scr ,eGFR and UTP with CKD3 in standard group illustrate statistics significance (P<0.05). On the opposite, those of the reference group remain insignificance (P > 0.05). The clinical curative effect result of patient in standard group was better than that of reference group. About the clinical curative effect of CKD4, no statistics significance difference (P > 0.05) could be found between groups or between patients in one group. The TCM score of patient with CKD3-4 in standard group have improved (P < 0.05) according to baseline. However, that of reference group did not show any statistics significance (P > 0.05). Conclusion Syndrome differentiation-based treatment with traditional Chinese medicine illustrated a better result in protection of renal function, reduction in urinary protein and decline in TCM score than the treatment according to experienced rule.
