Study on change of serum ghrelin and sex hormones levels in girls with precocious puberty
10.3969/j.issn.1673-4130.2014.15.006
- VernacularTitle:性早熟女童血清胃饥饿素与性激素水平变化研究
- Author:
Xiaojuan LUO
;
Ke CAO
;
Fanghua YANG
;
Xia LIU
;
Qin ZHANG
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
precocious puberty;
reproductive hormones;
enzyme-linked immunosorbent assay
- From:
International Journal of Laboratory Medicine
2014;(15):1981-1983
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of serum ghrelin and sex hormones levels in girls with precocious puberty . Methods 87 girls with precocious puberty were divided into the simple premature thelarche (SPT ) and central precocious puberty (CPP) groups according to the results of gonadotropin releasing hormone(GnRH) stimulation test ,size of ovary and uterus ,and de-velopmental status of the secondary sex characteristics ,with 34 age-matched healthy girls as control group .The serum ghrelin level was quantitatively measured by enzyme-linked immunosorbent assay (ELISA) ,luteinizing hormone(LH) ,follicle stimulating hor-mone(FSH) ,estradiol(E2) ,progesterone(PRGE) ,prolactin (PRL) ,testosterone (TSTO) and LH and FSH stimulated by GnRH after 30 ,60 ,90 min were measured by chemoluminescence technique .Results The ghrelin level in the CPP group was significantly higher than that in the control group(P<0 .05);there was no statistically significant difference between the SPT group and the control group and between the CPP group and the SPT group (P>0 .05) .The 5 indexes of sex hormone (LH ,FSH ,E2 ,PRL , PRGE) in the CPP group were significantly higher than those in the SPT group and the control group (P<0 .05) ,but no statisti-cally significant difference existed between the SPT group and the control group (P>0 .05);the TSTO level had no statistically sig-nificant difference among 3 groups(P>0 .05) .Conclusion The serum levels of ghrelin and 5 indexes of sex hormone (LH ,FSH , E2 ,PRL ,PRGE) in girls with CPP are significantly increased .
