Analysis on expression of activating and inhibitory receptors on peripheral natural killer cells in HBV-ACLF patients
10.3969/j.issn.1673-4130.2014.15.011
- VernacularTitle:HBV-ACLF患者外周血NK 细胞活化型受体和抑制型受体表达分析
- Author:
Junjie BAO
;
Yong ZOU
;
Xiaohong CHEN
;
Baidu ZHANG
- Publication Type:Journal Article
- Keywords:
hepatitis B virus;
liver falure;
receptor
- From:
International Journal of Laboratory Medicine
2014;(15):1993-1994
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of the activating and inhibitory receptors on periph-eral natural killer (NK) cells with the liver injury in the patients with hepatitis B virus related acute-on-chronic liver failure (HBV-ACLF) .Methods The peripheral blood samples were collected from 20 patients with HBV-ACLF and 20 patients with HBV-chro-nic hepatitis B(CHB) .The expressions of the activating receptors (NKP30 ,NKP46 ,NKG2D) and the inhibitory receptor (CD158a) on peripheral NK cells were detected by the multicolor flow cytometry .Results Compared with the HBV-CHB patients ,the ex-pression of the activating receptors NKP30 and NKP46 in the HBV-ACLF were remarkably unregulated(P<0 .05) ,but the expres-sion of the inhibitory receptor CD158a was markedly downregulated(P<0 .05) .Conclusion The enhanced expression of the activa-ting receptors NKP30 and NKP46 and the weakened expression of inhibitory receptor CD158a may be the important factor of the NK cells activation and the subsequent HBV-ACLF immune-mediated hepatocyte injury .
