Diagnostic value of soluble B7-H4 in rheumatoid arthritis
10.3969/j.issn.1673-4130.2014.15.013
- VernacularTitle:可溶性B7-H4在类风湿性关节炎中的诊断价值探讨
- Author:
Li MO
;
Jian JIANG
;
Jiongtao YAO
;
Xingquan TAN
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
enzyme-linked immunosorbent assay;
rheumatoid factor
- From:
International Journal of Laboratory Medicine
2014;(15):1997-1999
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis value of soluble B7-H4(sB7-H4) in rheumatoid arthritis (RA) .Methods By using the ELISA sandwich method ,the serum levels of soluble B7-H4 ,anti-cyclic citrullinated peptide(anti-CCP) antibody and glu-cose 6-phosphate isomerase(GPI) were detected in 67 cases of RA ,72 cases of osteoarthritis(OA) and 75 cases of healthy people . The immunoturbidimetric method was adopted to determine the serum rheumatoid factor (RF) .Then the diagnostic value of sB7-H4 in RA was compared and analyzed .Results The serum level of soluble B7-H4 in the RA group was significantly higher than that in the control group and the OA group with statistically significant difference between them (P<0 .01) .The sensitivity of sB7-H4 in diagnosing RA was higher than that of RF ,anti-CCP antibody and GPI ,but the specificity was lower than that of anti-CCP antibody and GPI .There was better correlation between sB7-H4 with RF and anti-CCP antibody .The combination detecting of sB7-H4 ,RF , anti-CCP antibody and GPI could increase the diagnostic rate of RA .Conclusion B7-H4 has better clinical application prospects in diagnosing RA .
