The study on serum level and clinical significance of anti-ribosomal protein P0 antibody in DLE and SLE patients
10.3969/j.issn.1006-5725.2014.16.020
- VernacularTitle:DLE和SLE患者血清中抗RPLP0抗体水平及临床意义
- Author:
Yanyu DU
;
Guozhen TAN
;
Ruixin YE
;
Jiaoxia CHEN
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus,Discoid;
Lupus erythematosus,systemic;
Cutaneous injury;
Anti-ribosomal P0 antibody
- From:
The Journal of Practical Medicine
2014;(16):2588-2591
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To study the serum level and the clinical significance of anti-ribosomal protein P0 antibody in discoid lupus erythematosus(DLE) and systemic lupus erythematosus(SLE) patients. Methods Serum anti-RPLP0 IgG antibody of 18 DLE patients and 23 SLE patients were tested by Enzyme-Linked Immunosorbent Assay (ELISA). Direct immunofluoreseence (DIF) was used to examined the immunoreaetants from skin lesion. Serum antibody and complement C3 were detected by conventional methods. Results Anti-ribosomal P0 antibody was higher in SLE patients (1.23 ± 0.62. mean ± SD) than in patients with DLE (0.53 ± 0.18, P<0.001) and healthy controls (0.72 ± 0.16, P<0.001), but was no difference in the later two groups (P=0.5). Among SLE patients , anti-ribosomal P0 protein antibody were much higher in patients with arthritis , nephritis and specific skin lesion than in those without these disorders (P<0.05). Anti-ribosomal P0 antibody was not associated with SLEDAI and CLASI(P=0.012). Conclusions There is no difference of serum anti-ribosomal P0 antibodies between healthy controls and DLE patients. SLE patients have higher level of serum anti-ribosomal P0 antibody , specially in those with specific skin lesion.
