Amlodipine inhibits cardiomyocyte remodeling by interfering ANP secretion
10.3969/j.issn.1006-5725.2014.15.003
- VernacularTitle:氨氯地平通过影响心房钠尿肽抑制心肌细胞的重构
- Author:
Qiuting FENG
;
Xiaojun QIAN
;
Xin XU
;
Chengjian YANG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Amlodipine;
Atrial natriuretic peptide;
Heart failure;
Cardiomyocyte remolding
- From:
The Journal of Practical Medicine
2014;(15):2360-2363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the dynamic changes of ANP during the diastolic heart failure and the protective effect of amlodipine. Methods Male SD rats underwent the abdominal aorta ligation. Four weeks after Surgery, 40 rats were divided into 4 groups: hypertension model group (group B), low-dose group (group C), mid-dose group (group D), high-dose group (group E). Another 10 healthy male SD rats were used as sham group (group A). During the experiment, different drugs were gavaged to different groups and the normal saline was used for control group. Results After 12 weeks, ANP levels increased in group B much more than in group A, while lower in group C(P < 0.05); LVSP and dp/dt max decreased in group B significantly than in group A, while higher in group C than in group B (P < 0.05); LVEDP and -dp/dt max had no statistically significant (P >0.05); HW/BW and LW/BW decreased in group B than in group A, while higher in group C than in group B (P < 0.05); The extent of myocardial necrosis and fibrosis in group C were much lower than in group B. But there was no Significant differences (P > 0.05). Conclusion ANP level gradually increased accompanying with the aggravation of heart failure, which is related with the dose of the drug within limits. Amlodipine can inhibit cardiomyocyte remodeling by interfering ANP secretion.
