Effect of terazosin on expressions of matrix metalloproteinase-9 and monocyte chemotactic protein 1 in a rat model of atherosclerosis
10.3969/j.issn.1006-5725.2014.15.007
- VernacularTitle:特拉唑嗪对大鼠动脉粥样硬化斑块中基质金属蛋白酶9与单核细胞趋化因子-1表达的影响
- Author:
Ling CHEN
;
Wei ZHOU
;
Manhua CHEN
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Terazosin;
Matrix metalloproteinase-9;
Monocyte chemotactic protein 1
- From:
The Journal of Practical Medicine
2014;(15):2373-2376
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of terazosin on expressions of matrix metalloproteinase-9 (MMP-9) and monocyte chemotactic protein 1 (MCP-1) in a rat model of atherosclerosis and to explore the mecha-nism for reducing atherosclerosis by terazosin. Methods Normal rats were fed with high lipid feedstuff to set up a rat model of atherosclerosis. Blood lipid indexes were measured and the expressions of MMP-9 and MCP-1 in aorta were detected and further quantified by immunohistochemistry after 12-week high lipid feedstuff. Results The plasma concentration of TG, TC, LDL in the terazosin group were significantly lower than those in the high cholesterol-diet group (P<0.01). The expressions of MMP-9 and MCP-1 in the high cholesterol-diet group and in the terazosin group were significantly higher than those in the normal-diet group (P < 0.01), but expressions of MMP-9 and MCP-1 in the terazosin group were significantly lower than those in the high cholesterol-diet group (P<0.01). Conclusion Terazosin can lower the concentration of TC, LDL but increase the HDL concentration. The anti-atherosclerotic mechanism of terazosin is associated with the decrease of the expressions of MMP-9 and MCP-1 and plasma lipoprotein.
