Relationship between MspⅠ polymorphism of CYP1A1 gene and susceptibility to breast cancer in Yi nationality in Yunnan province
10.3969/j.issn.1006-5725.2014.15.015
- VernacularTitle:云南省彝族及汉族乳腺癌遗传易感性与CYP1A1基因多态性的研究
- Author:
Ming ZHANG
;
Change GAO
;
Ying CHEN
;
Dedian CHEN
;
Tianning ZOU
;
Wenhui LI
;
Yi YANG
;
Ya LI
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
CYP1A1;
Msp I;
Polymorphism
- From:
The Journal of Practical Medicine
2014;(15):2398-2401
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between MspⅠpolymorphism of CYP1A1 gene and susceptibility to breast cancer in Yi nationality in Yunnan province. Methods The gene polymorphism of restriction enzyme of 3′-terminal of CYP1A1 was detected by PCR-RFLP in 60 healthy Yi women , 51 Yi women with breast cancer, 235 healthy Han women, and 250 Han women with breast cancer. Results The distribution frequency of CYP1A1-MspⅠgenotypes was significantly higher in Yi women with breast cancer (51.0%) than in the healthy Yi women (33.3%) (P < 0.05), an the allele C had a higher frequency in women with breast cancer than in healthy controls (P < 0.05). Significant differences of frequencies were found in genotypes TT, TC and CC between women with breast cancer and healthy controls (P < 0.05). The risks of TC and CC for breast cancer were 1.19 and 1.95 folds respectively to TT genotype. But as compared with Yi women , the distribution frequency of CYP1A1-MspⅠ genotypes did not differ between Han women with breast cancer and in the healthy control (P > 0.05), and there were no differences in three genotype frequencies (P > 0.05). Conclusions Gene polymorphism of CYP1A1 genotypes may be associated with the risk of breast cancer in Yi nationality but not in Han nationality in Yunnan. The mutation of CYP1A1 gene may increase the incidence of breast cancer in Yi nationality.
