Expression of KPNA2 in hepatocellular carcinoma
10.3969/j.issn.1673-4130.2014.15.027
- VernacularTitle:核转运蛋白受体在肝癌中的表达水平研究
- Author:
Feng LI
;
Zeyan PU
;
Fangjiu LIU
;
Rong WEI
;
Yanli LIANG
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
polymerase chain reaction;
diagnosis
- From:
International Journal of Laboratory Medicine
2014;(15):2031-2032
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the mRNA expression of KPNA2 in hepatocellular carcinoma(HCC) tissue and to investigate its relationship with the clinicopathological features of HCC so as to provide the basis for predicting HCC infiltration ,metastasis and early treatment .Methods The HCC tissue and paracarcinoma normal tissue from 30 operative cases of HCC in the hepatobiliary surgery department of this hospital from January 2011 to November 2013 were collected and detected KPNA2 expression at the transcriptional level by RT-PCR .The correlation between the mRNA expression of KPNA2 with the clinicopathological factors of HCC was analyzed by consulting the medical record data .Results Among 30 cases of HCC ,the ratio of KPNA2 mRNA in the HCC tissue and the paracarcinoma normal tissue in 25 cases(83 .33% ) was up-regulated (grey value >2 times) .Therefore ,the KP-NA2 gene exhibited the high expression in the HCC tissue and low expression in the paracarcinoma normal tissue .Conclusion KP-NA2 is highly expressed in the HCC tissue and lowly expressed in the paracarcinoma normal tissue ;the high expression of KPNA2 is positively correlated with the stage and pathological grading of HCC ;KPNA2 may be used as an important indicator for early di-agnosing HCC and judging the malignant degree and potential metastais ability of HCC .
