Genotype Distribution and Gene Frequency of Angiotensin I-Converting Enzyme in Korean Population.
- Author:
Young Mok YANG
1
;
Jong Hwan PARK
;
Eon Soo MOON
Author Information
1. Genetic Lab. of Premedical Course, Kon-Kuk University, College of Medicine, Chungju, Korea.
- Publication Type:Original Article
- Keywords:
Angiotensin I-converting enzyme;
ACE genotype;
Gene frequency;
Genetic polymorphism
- MeSH:
Adult;
Alleles;
Angiotensins*;
Base Sequence;
Female;
Gene Frequency*;
Genotype*;
Humans;
Hypertension;
Male;
Myocardial Infarction;
Peptidyl-Dipeptidase A*;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Renin-Angiotensin System;
Risk Factors
- From:Journal of Genetic Medicine
1997;1(1):17-22
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The angiotensin converting enzyme(ACE) is a key component of the renin-angiotensin system thought to be important in the pathogenesis of hypertension and cadiovascular diseases. Deletion polymorphism in the ACE gene may be a risk factor for myocardial infarction. The insertion/deletion(I/D) polymorphism of the ACE detected by PCR analysis appears to be associated with hypertension in Koreans and its nucleotide was subcloned into T-vector and its nucleotide sequences were determined. We also examined an association between hypertension and genetic variance of ACE. METHODS AND RESULTS: We identified the angiotensin I-converting enzyme genotype in 127 hypertensive and 189 normotensive Korean subjects. The distribution of ACE genotype II, ID, DD were 39.2%, 40.2%, 20.6% respectively and the frequency for ACE alleles I and D were 0.593 and 0.407, respecively in all subjects. The frequency of D allele in Korean males is higher than that of Korean females(male; 0.438 : female; 0.267), and the frequency of I allele in Korean females is higher than that of Korean males(female; 0.733 : male; 0.562). Genotype distributions of angiotensin I-converting enzyme genes in Korean normal adult population were different from that of Caucasians(P<0.001). There were no significant differences in genotype frequency between the hypertensive control group(n=127) and the normotensive group(n=189). CONCLUSIONS: We observed significant differences of ACE genotype distribution between the male group and the female group in total(P=0.001) and in hypertensive Korean subjects(P=0.013).
