Effects of statins atorvastatin calcium on cerebral carotid atherosclerotic plaque and efficacy of C-reactive protein
10.3760/cma.j.issn.1008-6706.2014.17.011
- VernacularTitle:阿托伐他汀钙对颈动脉粥样硬化斑块及C反应蛋白的影响
- Author:
Weidong JI
;
Yan FANG
;
Jingzhong WANG
- Publication Type:Journal Article
- Keywords:
Atorvastatin calcium;
Plaque,Atherosclerotic;
C-reactive protein
- From:
Chinese Journal of Primary Medicine and Pharmacy
2014;(17):2587-2588
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of statins atorvastatin calcium on cerebral carotid atherosclerotic plaques in patients and the effects on C-reactive protein .Methods 76 patients admitted to hospital with cerebral carotid atherosclerotic plaques in patients randomized manner using its divided into the observation group and control group of 38 patients in the control group not using statins , given only hospital conventional therapy , observed in the control group were given atorvastatin group based on calcium statin treatment ,post-treatment comparison groups the size of carotid atherosclerotic plaque and plasma C-reactive protein changes .Results After treatment , plaque size(0.069 ±0.021)cm2,IMT was (1.29 ±0.28)mm,significantly less than before treatment,after treatment difference was statistically significant (t=7.538,7.132,all P<0.05)also significantly less than the control group ,the difference was statistically significant (t=7.131,6.372,all P<0.05);the observation group after treatment C-reactive protein(3.54 ±1.92 ) mg/L, significantly lower than before treatment , before and after treatment difference was statistically significant(t=6.831,P<0.05),and significantly lower than the control group ,the difference was also statistically significant(t=7.125,P<0.05).Conclusion For patients with cerebral carotid atherosclerotic plaque is concerned,the application of atorvastatin calcium treatment can not only effectively reduce plaque area , but also reduce C-reactive protein,and therefore worthy of further clinical application .
